产品货号：
Z18496
中文名称：
HSD17B1抗体
英文名称：
Anti-HSD17B1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-HSD17B1 Antibody |
| 指标别名 | 17 beta HSD 1;20 alpha HSD;E17KSR;E2DH;EDH17B1;EDH17B2;EDHB17;HSD17;HSD17B1;SDR28C1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,rat |
| 应用范围 | WB,IHC,ICC |
| 基因名称 | HSD17B1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of human HSD17B1(29-43aa QSFKVYATLRDLKTQ),different from the related rat and mouse sequences by one amino acid. |
| 实际分子量 | 37～38KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Estradiol 17-beta-dehydrogenase 1 is an enzyme that in humans is encoded by the HSD17B1 gene.This gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases.It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues.The encoded protein catalyzes the last step in estrogen activation,using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione,to testosterone.It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site,and a narrow,hydrophobic C-terminal domain with a steroid substrate binding site.This gene is expressed primarily in the placenta and ovarian granulosa cells,and to a lesser extent,in the endometrium,adipose tissue,and prostate.Polymorphisms in this gene have been linked to breast and prostate cancer.A pseudogene of this gene has been identified.Alternative splicing results in multiple transcript variants. |
| Uniprot ID | P14061 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | hydroxysteroid(17-beta) dehydrogenase 1 |
| 蛋白名全称 | Estradiol 17-beta-dehydrogenase 1 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunocytochemistry in fixed cells (ICC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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